Similarity ensemble approach (SEA)
The SEA relates proteins based on set-wise chemical similarity among their ligands. It can be used to rapidly search large compound databases and to build cross-target similarity maps.
When using SEA, please cite:
Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK. Relating protein pharmacology by ligand chemistry. Nat Biotech 25 (2), 197-206 (2007).
Pubmed | DOI | PDF
SEA is provided by the Shoichet Laboratory in the Department of Pharmaceutical Chemistry at the University of California, San Francisco (UCSF).
Online search tool
The SEA search tool is now available. Click here.
- 06/29/2007 - Added Scitegic ECFP4 fingerprints and the WOMBAT database.
Precalculated results
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